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CRC Research
Analytical Methods5 min readAugust 19, 2025

Working with Analytical Reference Standards

How reference standards support calibration and method validation in a qualified analytical workflow.

The role of reference standards

Analytical reference standards provide a known point of comparison used to calibrate instruments and validate methods. They support consistency between measurements and across laboratories.

Reference standards should be handled and stored according to their accompanying documentation to preserve their reference value.

Good practice

Keep reference standards clearly labelled and separated from routine research materials, and retain their documentation for the life of the standard.

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