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CRC Research
Handling & Storage5 min readOctober 8, 2025

Laboratory Storage of Lyophilised Materials

General principles for storing lyophilised research materials to help preserve analytical integrity between receipt and use.

Why storage conditions matter

Lyophilised (freeze-dried) materials are generally more stable than materials in solution, but they still benefit from appropriate storage to preserve their analytical characteristics over time.

Manufacturer storage guidance is provided with each product and should always take precedence over general principles.

General handling principles

Store lyophilised material as directed, commonly at low temperature and protected from light and moisture.

Minimise unnecessary temperature cycling. Repeated freeze-thaw of reconstituted material is a common source of degradation.

Keep documentation with the material so batch identity and storage guidance remain accessible.

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